ISSN 2636-2937
 

Original Research (Original Article) 
JVS. 2018; 4(1): 57-71


Comparative Studies on Evaluation of Different Avian Influenza Inactivated Vaccines under Local Conditions in Egypt

nermeen ahmed marden, lamiaa mohamed gaafar, hussein Aly hussein.

Abstract
Background: Vaccination strategies have an important role in the limitation of viral infection and spread to the surrounding environment. The evaluation methods of the AI vaccines are very important for controlling the license of the bad vaccines. Comparative studies between the invitro and invivo methods for 8 types of AI vaccines (5 batches for each) to evaluate their efficacies were done.
Methods: The invivo method, was done through the vaccination-challenge pathway of SPF chickens to estimate the protection percent of each vaccine against both classical and variant HPAI viruses. While, the invitro method was done by the direct detection of the viral content and viral identity using the rRT-PCR technique from final product of these inactivated vaccines.
Results: The data of this study showed that sufficient HA antigen content and similar HA sequences with the field HPAI challenge viruses are needed to produce a consistent and high protection percent, but, they are not enough to assess the vaccine efficacy.
Conclusion: The invitro assessment of protection was not considered an alternative methods to the direct assessment of vaccine efficacy (vaccination-challenge), but it was used as complementary steps for vaccine evaluation protocol.

Key words: Keywords: avian influenza, inactivated vaccines, protection percent, vaccine viral strain and vaccine viral


 
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Pubmed Style

marden na, gaafar lm, hussein hA. Comparative Studies on Evaluation of Different Avian Influenza Inactivated Vaccines under Local Conditions in Egypt. JVS. 2018; 4(1): 57-71.


Web Style

marden na, gaafar lm, hussein hA. Comparative Studies on Evaluation of Different Avian Influenza Inactivated Vaccines under Local Conditions in Egypt. http://www.j-virol-sci.com/?mno=302642606 [Access: August 19, 2019].


AMA (American Medical Association) Style

marden na, gaafar lm, hussein hA. Comparative Studies on Evaluation of Different Avian Influenza Inactivated Vaccines under Local Conditions in Egypt. JVS. 2018; 4(1): 57-71.



Vancouver/ICMJE Style

marden na, gaafar lm, hussein hA. Comparative Studies on Evaluation of Different Avian Influenza Inactivated Vaccines under Local Conditions in Egypt. JVS. (2018), [cited August 19, 2019]; 4(1): 57-71.



Harvard Style

marden, n. a., gaafar, . l. m. & hussein, . h. A. (2018) Comparative Studies on Evaluation of Different Avian Influenza Inactivated Vaccines under Local Conditions in Egypt. JVS, 4 (1), 57-71.



Turabian Style

marden, nermeen ahmed, lamiaa mohamed gaafar, and hussein Aly hussein. 2018. Comparative Studies on Evaluation of Different Avian Influenza Inactivated Vaccines under Local Conditions in Egypt. Journal of Virological Sciences, 4 (1), 57-71.



Chicago Style

marden, nermeen ahmed, lamiaa mohamed gaafar, and hussein Aly hussein. "Comparative Studies on Evaluation of Different Avian Influenza Inactivated Vaccines under Local Conditions in Egypt." Journal of Virological Sciences 4 (2018), 57-71.



MLA (The Modern Language Association) Style

marden, nermeen ahmed, lamiaa mohamed gaafar, and hussein Aly hussein. "Comparative Studies on Evaluation of Different Avian Influenza Inactivated Vaccines under Local Conditions in Egypt." Journal of Virological Sciences 4.1 (2018), 57-71. Print.



APA (American Psychological Association) Style

marden, n. a., gaafar, . l. m. & hussein, . h. A. (2018) Comparative Studies on Evaluation of Different Avian Influenza Inactivated Vaccines under Local Conditions in Egypt. Journal of Virological Sciences, 4 (1), 57-71.





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